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The IRS1 (insulin receptor substrate 1) gene codes for a key protein in the insulin-stimulated signal pathway

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Concerning research gaps and opportunities, Rinaman pointed to whether perinatal development of the GLP-1/GLP-1R system may help explain individual differences in responsiveness to GLP-1R agonists, why there are sex differences in the endogenous GLP-1/GLP-1R system and why GLP-1R agonists are more effective for weight loss in women than in men, and whether chronic exposure to GLP-1R agonists affects central GLP-1 receptors